![]() ![]() During this process, the sample material is bombarded with a high-energy argon-ion beam to achieve high quality cross-sections and polished surfaces whilst minimizing deformation or damage. ![]() Today, ion beam milling is one of the most widely-used methods for preparing samples for electron microscopy. Extending Nanoscopy Possibilities with STED and exchangeable fluorophores A new approach enables whole cell, 3D, multi-color STED imaging as well as live-cell STED microscopy Nanoscopy meets Lifetime: Introducing τ-STED What’s behind the unique τ-STED functionality - new approach to STED based on fluorescence lifetime that delivers cutting-edge image quality and gentle live-cell conditions. The Guide to STED Sample Preparation The secrets behind successful STED imaging Which fluorescent labels can be used for single color STED imaging The right protocol to obtain high quality images, with a high signal/noise (S/N) ratio, of interesting structures in a specimen. Here are 3 practical application notes giving both an overview of the various cutting-edge implementations of STED nanoscopy and clear guidelines on successful STED imaging. ![]() Imaging beyond the diffraction limit STED super-resolution allows you to study multiple dynamic events simultaneously, so you can investigate molecular relationships and mechanisms within the cellular context. An understanding of how computational clearing improves the image quality of vitrified samples. How high pressure freezing allows millisecond freezing of larger samples. The importance of and strategies for keeping samples under cryo conditions throughout sample preparation workflows. How you can explore a particular time point of a cellular process at high resolution using optogenetics or electrical field stimulation in combination with HPF. These include: Key steps and instrumentation of cryo sample prep including vitrification, light microscopy screening, sectioning, planing, fracturing, milling, coating, and transfer. To help you achieve reliable and robust results in your cryo-EM workflows, we have collected and collated a selection of tools (AppNotes, Webinars, Tutorials) featuring different techniques and aspects of cryo-EM sample preparation. If you want to get the best results possible from cryo-EM you need to ensure you optimize the critical step of sample preparation. Find out about… The risks and difficulties caused by particulate contamination of pharmaceutical products and how to keep them under control How you can determine the shape, size, colour, and composition of particles more efficiently, reliably, and cost-effectively How to image and analyze your samples independently of the composition without the need for time-consuming sample preparation or sample transfer between multiple instruments The benefits of simultaneous visual and chemical particle analysis using the Leica DM6 M LIBS over conventional SEM/EDS root cause analysis workflows Download this E-Guide and learn more about the Leica DM6 M LIBS and how your material analysis for contamination identification and root cause analysis can benefit.Ĭryo-electron microscopy (cryo-EM) allows the visualization of biomolecules, from proteins to viruses, and allows snapshots of cellular processes and protein interactions to be seen at high resolution. An innovative 2-in-1 method for materials analysis makes visual and chemical particle analysis faster, easier, and more cost-effective. Find out how to quickly identify particle contamination in medicine production Identifying and eliminating particulate contamination in pharmaceutical products is often complex, time-consuming, and requires the particles to be relocated. ![]()
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