![]() ![]() ![]() Gastro-oesophageal reflux disease (GORD) is a relatively common condition, affecting 10–29% of the Western population and 5–14% of Japanese adults, and is associated with a variety of respiratory disorders. 1 Several clinical backgrounds are reportedly associated with exacerbation frequency, including age, low forced expiratory volume in 1 s (FEV 1) and low body mass index (BMI). EBC pH was inversely correlated with FSSG score in both groups (p = 0.01, r = –0.37, 95% CI –0.55 to −0.14 in patients with COPD, and p<0.01, r = –0.45, 95% CI –0.67 to −0.16 in control subjects).Ĭonclusions: GORD symptoms were identified as an important factor associated with COPD exacerbation.Įxacerbations of chronic obstructive pulmonary disease (COPD) are an important determinant of patient quality of life and can aggravate disease progression, which is associated with increased morbidity and use of healthcare resources. Multiple regression analysis revealed that GORD symptoms were significantly associated with the occurrence of exacerbations (p<0.01 relative risk 6.55, 95% CI 1.86 to 23.11). The frequency of exacerbations was significantly associated with the FSSG score (p = 0.03, r = 0.24, 95% CI 0.02 to 0.43). Results: Positive GORD symptoms were reported in 22 (26.8%) patients with COPD and in five (12.5%) controls (p = 0.10). Exhaled breath condensate (EBC) pH was measured in both groups, and induced sputum was evaluated in patients with COPD. Patients with COPD were prospectively surveyed for 6 months, and episodes of exacerbation were identified using a diary based on modified Anthonisen’s criteria. Symptoms were evaluated by a questionnaire using the Frequency Scale for the Symptoms of GORD (FSSG). Methods: 82 patients with COPD and 40 age matched controls were enrolled in this study. Objective: To prospectively establish the clinical significance of GORD symptoms on exacerbation. Background: The association between gastro-oesophageal reflux disease (GORD) and chronic obstructive pulmonary disease (COPD) exacerbation has so far remained unclear. ![]()
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